Glaucoma References:

  • McKinnon, S.J., Lehman, D.M., Kerrigan-Baumrind, L.A., Merges, C.A., Pease, M.E., Kerrigan, D.F., Ransom, N.L., Tahzib, N.G., Reitsamer, H.A., Levkovitch-Verbin, H., Quigley, H.A. and Zack, D.J. (2002). Caspase activation and amyloid precursor protein cleavage in rat ocular hypertension. Invest Ophthalmol Vis Sci 43(4): 1077-1087.
  • Walsh, D.T., Bresciani, L., Saunders, D., Manca, M.F., Jen, A., Gentleman, S.M. and Jen, L.S. (2005). Amyloid beta peptide causes chronic glial cell activation and neuro-degeneration after intravitreal injection. Neuropathol Appl Neurobiol 31(5): 491-502.
  • Goldblum, D., Kipfer-Kauer, A., Sarra, G.M., Wolf, S. and Frueh, B.E. (2007). Distribution of amyloid precursor protein and amyloid-beta immunoreactivity in DBA/2J glaucomatous mouse retinas. Invest Ophthalmol Vis Sci 48(11): 5085-5090.
  • Guo, L., Salt, T.E., Luong, V., Wood, N., Cheung, W., Maass, A., Ferrari, G., Russo-Marie, F., Sillito, A.M., Cheetham, M.E., Moss, S.E., Fitzke, F.W. and Cordeiro, M.F. (2007). Targeting amyloid-beta in glaucoma treatment. Proc Natl Acad Sci U S A 104(33): 13444-13449.
  • Bruban, J., Glotin, A.L., Dinet, V., Chalour, N., Sennlaub, F., Jonet, L., An, N., Faussat, A.M. and Mascarelli, F. (2009). Amyloid-beta(1-42) alters structure and function of retinal pigmented epithelial cells. Aging Cell 8(2): 162-177.
  • Kipfer-Kauer, A., McKinnon, S.J., Frueh, B.E. and Goldblum, D. (2010). Distribution of amyloid precursor protein and amyloid-beta in ocular hypertensive C57BL/6 mouse eyes. Curr Eye Res 35(9): 828-834.
  • Tsuruma, K., Tanaka, Y., Shimazawa, M. and Hara, H. (2010). Induction of amyloid precursor protein by the neurotoxic peptide, amyloid-beta 25-35, causes retinal ganglion cell death. J Neurochem 113(6): 1545-1554.
  • Böhm, N., Gramlich, O. and Grus, F. (2012). Analysis of ß-Amyloid deposition in human glaucomatous retinae, a proteochemcial and immunohistochemical approach. Report: 1-32.
  • Salt, T.E., Nizari, S., Cordeiro, M.F., Russ, H. and Danysz, W. (2014). Effect of the Abeta aggregation modulator MRZ-99030 on retinal damage in an animal model of glaucoma. Neurotox Res 26(4): 440-446.
  • Ratnayaka, J.A., Serpell, L.C. and Lotery, A.J. (2015). Dementia of the eye: the role of amyloid beta in retinal degeneration. Eye (Lond) 29(8): 1013-1026

Dry AMD References:

  • Bradt, B.M., Kolb, W.P. and Cooper, N.R. (1998). Complement-dependent proinflammatory properties of the Alzheimer's disease beta-peptide. J Exp Med 188(3): 431-438.
  • Mullins, R.F., Russell, S.R., Anderson, D.H. and Hageman, G.S. (2000). Drusen associated with aging and age-related macular degeneration contain proteins common to extracellular deposits associated with atherosclerosis, elastosis, amyloidosis, and dense deposit disease. FASEB J 14(7): 835-846.
  • Dentchev, T., Milam, A.H., Lee, V.M., Trojanowski, J.Q. and Dunaief, J.L. (2003). Amyloid-beta is found in drusen from some age-related macular degeneration retinas, but not in drusen from normal retinas. Mol Vis 9: 184-190.
  • Yoshida, T., Ohno-Matsui, K., Ichinose, S., Sato, T., Iwata, N., Saido, T.C., Hisatomi, T., Mochizuki, M. and Morita, I. (2005). The potential role of amyloid beta in the pathogenesis of age-related macular degeneration. J Clin Invest 115(10): 2793-2800.
  • Malek, G., Johnson, L.V., Mace, B.E., Saloupis, P., Schmechel, D.E., Rickman, D.W., Toth, C.A., Sullivan, P.M. and Bowes Rickman, C. (2005). Apolipoprotein E allele-dependent pathogenesis: a model for age-related retinal degeneration. Proc Natl Acad Sci U S A 102(33): 11900-11905.
  • Luibl, V., Isas, J.M., Kayed, R., Glabe, C.G., Langen, R. and Chen, J. (2006). Drusen deposits associated with aging and age-related macular degeneration contain nonfibrillar amyloid oligomers. J Clin Invest 116(2): 378-385.
  • Ding, J.D., Lin, J., Mace, B.E., Herrmann, R., Sullivan, P. and Bowes Rickman, C. (2008). Targeting age-related macular degeneration with Alzheimer's disease based immunotherapies: anti-amyloid-beta antibody attenuates pathologies in an age-related macular degeneration mouse model. Vision Res 48(3): 339-345.
  • Bruban, J., Glotin, A.L., Dinet, V., Chalour, N., Sennlaub, F., Jonet, L., An, N., Faussat, A.M. and Mascarelli, F. (2009). Amyloid-beta(1-42) alters structure and function of retinal pigmented epithelial cells. Aging Cell 8(2): 162-177.
  • Tsuruma, K., Tanaka, Y., Shimazawa, M. and Hara, H. (2010). Induction of amyloid precursor protein by the neurotoxic peptide, amyloid-beta 25-35, causes retinal ganglion cell death. J Neurochem 113(6): 1545-1554.
  • Ratnayaka, J.A., Serpell, L.C. and Lotery, A.J. (2015). Dementia of the eye: the role of amyloid beta in retinal degeneration. Eye (Lond) 29(8): 1013-1026.
  • Guymer, R., Cipriani, T., Rittenhouse, K.D., Lim, L., Robman, L.D., Li, W., Wang, W., Deng, S. and Banerjee, P. (2015). Plasma levels of amyloid beta and other proinflammatory mediators in patients with age-related macular degeneration. Graefes Arch Clin Exp Ophthalmol 253(8): 1347-1354.